Help find a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff

yup

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Also here: https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,45879_lastpage,yes#691590

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Got a buncha MCMs too!!! :+1:

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I just do a Tools—>Retry pending transfers and after trying that a couple of times it uploaded my MCM jobs but it hasn’t downloaded anything new and tells me “Communication deferred”

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A few people out on Facebook commenting that they haven’t had any work to do for days. I’ve switched over to an amicable numbers project which is probably fairly pointless in life, but I don’t know what else to choose.

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You guys pick your projects? I think I just let them assign me whatever.

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Africa Rainfall was a pig to run, so I unchecked it from my list for a while. :hourglass_flowing_sand:

Space Lobster moves up a spot, and I added two names that weren’t on here previously

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Here’s the highly anticipated yet much delayed monthly update on World Community Grid points:

Member Name           Points    Monthly
                   Generated     Change
mbplatt          213,217,809  3,781,510
KlaymenAO        186,779,235  2,624,903
1695814           92,728,837    991,699
Wannabe Actuary   70,889,713  1,260,416
Macroman          61,263,705    720,173
SpaceLobster      11,798,653    593,016
Breadmaker        11,612,546    291,153
meepbobeep        11,035,034    111,072
GoA_Kenny            733,504    166,999

@SpaceLobster leaps ahead of @Breadmaker.

Statistics last updated: 12/5/23 23:59:59 (UTC) [29 hour(s) ago]

Available WCG Projects:
OpenPandemics - COVID-19
Africa Rainfall Project
Help Stop TB
Mapping Cancer Markers
Smash Childhood Cancer

WCG discussion forums can be found here .

Here’s the monthly update on Folding@Home points:

                          Monthly
Name            Credit     Change
1695814     32,471,238    368,008
Breadmaker   4,961,319     93,620
GoA_Kenny    5,468,591    532,321
yoyo         2,007,297  2,007,297

Welcome into the folding, @yoyo.

Typical Folding@Home Projects

COVID-19
Alzheimer’s
Cancer
Huntington’s
Parkinson’s
For a comprehensive list see https://apps.foldingathome.org/psummary

If you’d like to join us in finding a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff, see the OP ( <-- clicky clicky! ) for links to get the downloads

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Monthly change of 0 is suspicious

They did say on their website they were just getting things going a day or two ago and I got a few tasks from them but that was it haven’t checked today yet

I’ve only been getting tasks occasionally the last couple weeks. It does help to manually request tasks but this doesn’t always work and I’m not going to sit around babysitting the computer.

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Ain’t nobody got time for that!

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Here’s the monthly update on World Community Grid points:

Member Name           Points    Monthly
                   Generated     Change
mbplatt          216,243,552  3,025,743
KlaymenAO        187,413,008    633,773
1695814           93,054,782    325,945
Wannabe Actuary   71,692,454    802,741
Macroman          61,405,491    141,786
yoyo_58           36,621,532        519
SpaceLobster      12,412,006    613,353
Breadmaker        11,682,610     70,064
meepbobeep        11,062,325     27,291
GoA_Kenny            918,318    184,814

Statistics last updated: 1/1/24 23:59:59 (UTC) [2 hour(s) ago]

Available WCG Projects:
OpenPandemics - COVID-19
Africa Rainfall Project
Help Stop TB
Mapping Cancer Markers
Smash Childhood Cancer

WCG discussion forums can be found here .

Here’s the monthly update on Folding@Home points:

                          Monthly
Name            Credit     Change
1695814     33,013,530    542,292
Breadmaker   4,985,039     23,720
GoA_Kenny    6,035,700    567,109
yoyo         3,595,499  1,588,202

Typical Folding@Home Projects

COVID-19
Alzheimer’s
Cancer
Huntington’s
Parkinson’s
For a comprehensive list see https://apps.foldingathome.org/psummary

If you’d like to join us in finding a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff, see the OP ( <-- clicky clicky! ) for links to get the downloads

2 Likes

Facebook post:

The MCM team continues their work on characterizing lung cancer biomarkers identified in the MCM1 project. PCSK5 is a gene associated with lung cancer survival, which shows differential expression across various cancer types. Read more here:

full text plus some pretty pictures

Research update from the MCM team (January 2024)

We continue our work on characterizing lung cancer biomarkers identified in the MCM1 project. This update focuses on PCSK5, a gene associated with lung cancer survival and which shows differential expression across various cancer types.


Project: Mapping Cancer Markers

Published on: 16 Jan 2024


Terminology

- Proprotein: An inactive protein that can be modified to become an active protein.

- VACTERL association: A complex condition characterized by multiple congenital anatomical defects, including vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities (VACTERL).

- Herlyn-Werner-Wunderlich syndrome: A rare congenital disorder characterized by anatomical defects in the urogenital tract.

Background

Precision medicine is enabled by using molecular markers (signatures) that identify disease early, and stratify patients into subgroups with different disease progression patterns, leading to potentially different treatment strategies. The Mapping Cancer Markers project analyzes data sets with millions of data points collected from patients with cancers and sarcomas to find such diagnostic, prognostic and predictive signatures.

Since November 2013, World Community Grid volunteers have donated over 875,900 CPU years to the project, helping analyse data on lung and ovarian cancer and sarcoma, much more thoroughly than otherwise possible. We are immensely grateful for the volunteers who continue to donate to this project.

Further characterising the 26 top-scoring genes in lung cancer, we have already discussed VAMP1, FARP1, GSDMB, ADH6, and IL13RA1 (in our March, April, July, September, and November 2023 updates). Here, we outline information on PCSK5.

PCSK5 Research

PCSK5 encodes proprotein convertase subtilisin/kexin type 5, a serine endoproteinase that processes different proproteins (Uniprot). PCSK5 has been implicated in diverse biological processes. Studies in mice have revealed that it is involved in early heart development[1] and ovarian follicle development[2]. Another study suggested that it may facilitate SARS-CoV-2 entry into myocardial tissue[3]. Genetic variation in PCSK5 has been demonstrated to modulate high-density lipoprotein (HDL) cholesterol levels[4]. In addition to its association with cancer, links have been identified between PCSK5 and other diseases. For example, mutations in PCSK5 have been identified in patients with the VACTERL association[5] and Herlyn-Werner-Wunderlich syndrome[6]. PCSK5 has also been identified as a diagnostic biomarker for endometriosis[7] and inflammatory skin disease[8].

As with the other genes we have presented, we found that PCSK5 has a protective role in lung cancer (Figure 1).

Figure 1. Survival curves for patients with high and low expression of PCSK5 (KMplot).

We investigated further to see if this finding is seen in other cancers. As shown in Figure 2, PCSK5 is differentially expressed in normal tissue compared with cancer tissue across most cancer types (red labels). In most of the cases, it is the loss of PCSK5 expression that is associated with cancer, except liver, renal, stomach and testicular cancers. The literature also supports this observation, as associations have been documented between PCSK5 expression and colorectal cancer[9], brain cancer[10], osteosarcoma[11], and renal cancer[12].

Figure 2. Expression of PCSK5 in normal and cancer tissue for multiple cancer types. Red text represents a significant difference between expression in cancer tissue compared with normal tissue (TNMplot).

If you have any questions or comments, please leave them in this thread for us to answer. Thank you for your support!

WCG Team

References

  1. Szumska D, Cioroch M, Keeling A, Prat A, Seidah NG, Bhattacharya S. Pcsk5 is required in the early cranio-cardiac mesoderm for heart development. BMC Dev Biol. 2017 Apr 26;17(1):6. doi: 10.1186/s12861-017-0148-y. PMID: 28446132; PMCID: PMC5407003.
  2. Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK. Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates. PLoS One. 2011 Mar 8;6(3):e17348. doi: 10.1371/journal.pone.0017348. PMID: 21408162; PMCID: PMC3050889.​​​​​​
  3. Chen C, Wang J, Liu YM, Hu J. Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2. J Transl Med. 2023 May 31;21(1):358. doi: 10.1186/s12967-023-04224-1. PMID: 37259108; PMCID: PMC10231857.
  4. Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circ Cardiovasc Genet. 2009 Oct;2(5):467-75. doi: 10.1161/CIRCGENETICS.109.877811. Epub 2009 Aug 22. PMID: 20031622; PMCID: PMC2901678.
  5. Nakamura Y, Kikugawa S, Seki S, Takahata M, Iwasaki N, Terai H, Matsubara M, Fujioka F, Inagaki H, Kobayashi T, Kimura T, Kurahashi H, Kato H. PCSK5 mutation in a patient with the VACTERL association. BMC Res Notes. 2015 Jun 9;8:228. doi: 10.1186/s13104-015-1166-0. PMID: 26055999; PMCID: PMC4467638.
  6. Li L, Chu C, Li S, Lu D, Zheng P, Sheng J, Luo LJ, Wu X, Zhang YD, Yin C, Duan AH. Renal agenesis-related genes are associated with Herlyn-Werner-Wunderlich syndrome. Fertil Steril. 2021 Nov;116(5):1360-1369. doi: 10.1016/j.fertnstert.2021.06.033. Epub 2021 Jul 24. PMID: 34311961.
  7. Zhang H, Zhang H, Yang H, Shuid AN, Sandai D, Chen X. Machine learning-based integrated identification of predictive combined diagnostic biomarkers for endometriosis. Front Genet. 2023 Nov 27;14:1290036. doi: 10.3389/fgene.2023.1290036. PMID: 38098472; PMCID: PMC10720908.
  8. Bang H, Kim JE, Lee HS, Park SM, Park DJ, Lee EJ. Integrated bioinformatic analysis of gene expression profiling data to identify combinatorial biomarkers in inflammatory skin disease. Sci Rep. 2022 Apr 7;12(1):5889. doi: 10.1038/s41598-022-09840-3. PMID: 35393522; PMCID: PMC8989986.
  9. Liao C, Huang X, Gong Y, Lin Q. Discovery of core genes in colorectal cancer by weighted gene co-expression network analysis. Oncol Lett. 2019 Sep;18(3):3137-3149. doi: 10.3892/ol.2019.10605. Epub 2019 Jul 11. PMID: 31402962; PMCID: PMC6676736.
  10. Yuan Y, Qi P, Xiang W, Yanhui L, Yu L, Qing M. Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma. Front Genet. 2020 Nov 26;11:565341. doi: 10.3389/fgene.2020.565341. PMID: 33324446; PMCID: PMC7726196.
  11. Gao M, Liu W, Li T, Song Z, Wang X, Zhang X. Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs. Biochem Genet. 2023 Sep 6. doi: 10.1007/s10528-023-10497-4. Epub ahead of print. PMID: 37672187.
  12. Poplawski P, Alseekh S, Jankowska U, Skupien-Rabian B, Iwanicka-Nowicka R, Kossowska H, Fogtman A, Rybicka B, Bogusławska J, Adamiok-Ostrowska A, Hanusek K, Hanusek J, Koblowska M, Fernie AR, Piekiełko-Witkowska A. Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration. Cancer Cell Int. 2023 Jan 5;23(1):2. doi: 10.1186/s12935-022-02845-y. PMID: 36604669; PMCID: PMC9814214.
tl;dr via chatgpt

The MCM team’s January 2024 update focuses on the gene PCSK5 in lung cancer research. PCSK5, associated with lung cancer survival, is a proprotein convertase involved in various biological processes. The study explores its role in heart and ovarian development and its associations with diseases like VACTERL syndrome. PCSK5 shows a protective role in lung cancer and varied expression in different cancer types. The research aims to identify molecular markers for early disease detection and personalized treatment strategies in precision medicine.

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Here’s the monthly update on World Community Grid points:

Member Name           Points    Monthly
                   Generated     Change
mbplatt          220,111,411  3,867,859
KlaymenAO        194,038,153  6,625,145
1695814           93,438,462    383,680
Wannabe Actuary   72,160,256    467,802
Macroman          61,941,427    535,936
yoyo_58           36,621,532           
SpaceLobster      13,140,550    728,544
Breadmaker        11,729,337     46,727
meepbobeep        11,182,708    120,383
GoA_Kenny          1,013,398     95,080

Statistics last updated: 1/31/24 23:59:59 (UTC) [2 hour(s) ago]

@yoyo seems to be shutting down. Well, here’s hoping he can bounce back like a …I don’t know…something that comes back up after being down…a toy of some sort…a rubber ball, perhaps.

Available WCG Projects:
OpenPandemics - COVID-19
Africa Rainfall Project
Help Stop TB
Mapping Cancer Markers
Smash Childhood Cancer

WCG discussion forums can be found here .

Here’s the monthly update on Folding@Home points:

                          Monthly
Name            Credit     Change
1695814     33,630,006    616,476
GoA_Kenny    6,189,498    153,798
yoyo         5,289,632  1,694,133
Breadmaker   4,994,669      9,630

Never mind what I said about @yoyo. He’s kicking it up a notch in Folding@Home.

Typical Folding@Home Projects

COVID-19
Alzheimer’s
Cancer
Huntington’s
Parkinson’s
For a comprehensive list see https://apps.foldingathome.org/psummary

If you’d like to join us in finding a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff, see the OP ( <-- clicky clicky! ) for links to get the downloads

1 Like

The Open Pandemics team has released new work units, which are targeting the DNA polymerase of cytomegalovirus. Read more here:

…or here…

Research update from the OPN team (February 2024)

The Open Pandemics team has released new work units, which are targeting the DNA polymerase of cytomegalovirus.


Project: OpenPandemics - COVID-19

Published on: 14 Feb 2024


Terminology

- DNA polymerase: An enzyme, made up of multiple subunits, that builds DNA by assembling nucleotides.

Background

Scientists at Scripps Research are doing molecular modeling simulations to look for possible candidates for the development of treatments for viruses, including COVID-19. This research requires massive computing power to carry out millions of simulated laboratory experiments. The molecules identified as promising candidates are then tested in laboratories by collaborators of the OPN team.

Work unit update

New work units are targeting the DNA polymerase of cytomegalovirus, a common virus which is particularly harmful to pregnant or immunocompromised individuals. The goal is to identify small molecule binders to one of the polymerase subunits, preventing its interaction with another polymerase subunit, and thereby disrupting the assembly of a functional polymerase. About 40 million molecules from Enamine will be simulated to identify candidates for purchase and evaluation by our collaborators.

Figure 1. Cytomegalovirus infection of pneumocytes (Image Author: Dr. Yale Rosen, USA. Image licenced under the Creative Commons Attribution-Share Alike 2.0 Generic Licence)

Via the site formally known as FaceBook:

text

Research Update from the MCM Team (February 2024)

We continue our work on characterising lung cancer biomarkers identified in the MCM1 project. This update focuses on a transcriptional corepressor TLE3.


Project: Mapping Cancer Markers

Published on: 16 Feb 2024


Terminology

- Transcription factor: A protein that binds to DNA to control the rate at which DNA is transcribed to messenger RNA.

- Trancriptional corepressor: A protein that indirectly represses expression of genes by binding to transcription factors.

- Sheehan’s syndrome: Postpartum anterior pituitary hormone deficiency due to necrosis of the pituitary gland. This is usually the result of massive hemorrhage during or after delivery.

Background

Identifying molecular markers and their combination (signatures) enables us to detect disease earlier (diagnostic signatures) and stratify patients into subgroups based on disease progression patterns (prognostic signatures), potentially leading to identifying which patients may benefit from what treatment (predictive signatures). The Mapping Cancer Markers project analyzes data sets with millions of data points collected from patients with cancers and sarcomas to find such diagnostic, prognostic and predictive signatures.

Since November 2013, World Community Grid volunteers have donated over 887,100 CPU years to the project, helping analyse data on lung and ovarian cancer and sarcoma, much more thoroughly than otherwise possible. We are immensely grateful for this continued support.

Further characterising the 26 top-scoring genes in lung cancer, we have already discussed VAMP1, FARP1, GSDMB, ADH6, IL13RA1, and PCSK5 in previous MCM updates. Here, we outline information on TLE3.

TLE3 Research

TLE3 encodes a protein called transducin-like enhancer protein 3, which is a transcriptional corepressor that binds to several transcription factors (Uniprot). TLE3 has been implicated in immune functions. Studies have suggested that TLE3 promotes memory B cell development[1] and is involved in the maintenance of intestinal immune homeostasis[2]. One study also found that TLE3 expression was significantly increased in patients with Sheehan’s syndrome compared to controls[3].

TLE3 was found to have a protective role in lung cancer, in line with the genes we have previously presented (Figure 1).

Figure 1. Survival curves for patients with high and low expression of TLE3 (KMplot).

This overall survival trend is even stronger for females, as depicted in Figure 2.

Figure 2. Survival curves for female lung cancer patients with high and low expression of TLE3 (KMplot).

We investigated further to see whether TLE3 expression was also associated with other cancers. As shown in Figure 3, comparing cancer to normal tissue, TLE3 is differentially expressed across most cancers (highlighted with red font). Within the literature, TLE3 expression has been associated with melanoma[4], rhabdomyosarcoma[5], ovarian cancer responsiveness to treatment[6], breast cancer prognosis[7] and responsiveness to treatment[8].

Figure 3. Expression of TLE3 in normal and cancer tissue for multiple cancer types. Red text represents a significant difference between expression in cancer tissue compared with normal tissue (TNMplot).

If you have any questions or comments, please leave them in this thread for us to answer!

WCG Team

References

  1. Laidlaw BJ, Duan L, Xu Y, Vazquez SE, Cyster JG. The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nat Immunol. 2020 Sep;21(9):1082-1093. doi: 10.1038/s41590-020-0713-6. Epub 2020 Jun 29. PMID: 32601467; PMCID: PMC7442689.
  2. Li X, Zhang B, Zhang X, Yu S, Xue HH, Hu X. TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis. Mucosal Immunol. 2023 Feb;16(1):50-60. doi: 10.1016/j.mucimm.2022.12.005. Epub 2023 Jan 2. PMID: 36801171.
  3. Diri H, Sener EF, Bayram F, Dundar M, Simsek Y, Baspinar O, Zararsiz G. Genetic disorders of pituitary development in patients with Sheehan’s synfrome. Acta Endocrinol (Buchar). 2016 Oct-Dec;12(4):413-417. doi: 10.4183/aeb.2016.413. PMID: 31149124; PMCID: PMC6535245.
  4. Ogawa M, Yaginuma T, Nakatomi C, Nakajima T, Tada-Shigeyama Y, Addison WN, Urata M, Matsubara T, Watanabe K, Matsuo K, Sato T, Honda H, Hikiji H, Watanabe S, Kokabu S. Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity. Oncotarget. 2019 Jan 8;10(3):404-414. doi: 10.18632/oncotarget.26552. PMID: 30719233; PMCID: PMC6349449.
  5. Kalita B, Sahu S, Bharadwaj A, Panneerselvam L, Martinez-Cebrian G, Agarwal M, Mathew SJ. The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma. Oncogene. 2024 Feb;43(7):524-538. doi: 10.1038/s41388-023-02911-3. Epub 2024 Jan 4. PMID: 38177411.
  6. Ring BZ, Murali R, Soslow RA, Bowtell DDL, Fereday S, deFazio A, Traficante N, Kennedy CJ, Brand A, Sharma R, Harnett P, Samimi G; Australian Ovarian Cancer Study. Transducin-Like Enhancer of Split 3 (TLE3) Expression Is Associated with Taxane Sensitivity in Nonserous Ovarian Carcinoma in a Three-Cohort Study. Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):680-688. doi: 10.1158/1055-9965.EPI-17-1101. Epub 2018 Mar 12. PMID: 29531130; PMCID: PMC5984690.
  7. Anstine LJ, Majmudar PR, Aponte A, Singh S, Zhao R, Weber-Bonk KL, Abdul-Karim FW, Valentine M, Seachrist DD, Grennel-Nickelson KE, Cuellar-Vite L, Sizemore GM, Sizemore ST, Webb BM, Thompson CL, Keri RA. TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis. Cancer Res. 2023 Apr 4;83(7):997-1015. doi: 10.1158/0008-5472.CAN-22-3133. PMID: 36696357; PMCID: PMC10089698.
  8. Kashiwagi S, Fukushima W, Asano Y, Goto W, Takada K, Noda S, Takashima T, Onoda N, Ohsawa M, Hirakawa K, Ohira M. Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer. BMC Cancer. 2017 Aug 31;17(1):604. doi: 10.1186/s12885-017-3598-5. PMID: 28859615; PMCID: PMC5580315.
chatgpt summary

Summary:

The MCM Team’s research update for February 2024 focuses on characterizing lung cancer biomarkers, particularly the transcriptional corepressor TLE3, within the Mapping Cancer Markers project. TLE3 encodes a protein involved in immune functions and has been found to have a protective role in lung cancer. The study indicates that TLE3 expression is associated with various cancers, including melanoma, rhabdomyosarcoma, ovarian cancer, breast cancer, and more. The research also explores TLE3’s differential expression in normal and cancer tissues across multiple cancer types. Notably, TLE3 shows increased expression in patients with Sheehan’s syndrome. The findings suggest TLE3’s potential as a marker for cancer prognosis, responsiveness to treatment, and its role in maintaining immune homeostasis. The update includes survival curves illustrating the impact of TLE3 expression on overall survival, particularly in female lung cancer patients.

1 Like

via faceoff…for the pimple-faced-kids…

Key points from chat gpt which is just about as long as the article itself, which was quite succinct, I must say:

Key Points:

  1. Competition Announcement: The Science Commons Initiative has announced the Computation Moonshoot Competition, encouraging high school students to learn about data science and distributed computing using BOINC and World Community Grid.
  2. Competition Duration: The competition will take place from March 25 to May 7, 2024.
  3. Objective: The competition aims to have students contribute to real, useful outcomes for researchers in a competitive atmosphere.
  4. Organizer: The Science Commons Initiative is organizing the competition.
  5. Eligibility: The main competition is open to all United States high schools and their students, with the potential for global interest.
  6. Prizes: Prizes will be awarded to schools with the most active contributors, the most processing time contributed, and the highest ratio of active contributors to students. Prizes include science equipment, gift cards, and student scholarships.
  7. Background: This is not the first grid computing competition on World Community Grid. Previous competitions by other schools have demonstrated significant contributions to research projects.
  8. Learning Opportunities: Previous experiences from high schools show that such competitions provide valuable learning opportunities for students and serve as an exciting way to motivate them about grid computing.
  9. Growing Participation: Several high schools, including Stockholm Science and Innovation School in Sweden, Sisler High School in Canada, and Boca Raton Community High School, have been actively involved in grid computing competitions and projects.
  10. Registration: Registration for the Computation Moonshoot competition is open, and more information can be found on the competition’s official website.

Here’s the monthly update on World Community Grid points:

Member Name           Points    Monthly
                   Generated     Change
mbplatt          224,478,702  4,367,291
KlaymenAO        200,903,011  6,864,858
1695814           93,764,310    325,848
Wannabe Actuary   73,091,416    931,160
Macroman          62,435,907    494,480
SpaceLobster      13,792,991    652,441
Breadmaker        11,830,475    101,138
meepbobeep        11,417,674    234,966
EffNine            1,754,460      3,789
GoA_Kenny          1,165,944    152,546

Welcome back, to EffNine & a fond farewell to yoyo_58.

Statistics last updated: 2/29/24 23:59:59 (UTC) [14 hour(s) ago]

Available WCG Projects:
OpenPandemics - COVID-19
Africa Rainfall Project
Help Stop TB
Mapping Cancer Markers
Smash Childhood Cancer

WCG discussion forums can be found here .

Here’s the monthly update on Folding@Home points:

                          Monthly
Name            Credit     Change
1695814     34,263,513    633,507
GoA_Kenny    6,744,643    555,145
yoyo         7,470,283  2,180,651
Breadmaker   4,994,669           

Welcome, full time, to the folding party, yoyo. Has @Breadmaker found too many raisins in the folds of his proteins?

Typical Folding@Home Projects

COVID-19
Alzheimer’s
Cancer
Huntington’s
Parkinson’s
For a comprehensive list see https://apps.foldingathome.org/psummary

If you’d like to join us in finding a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff, see the OP ( <-- clicky clicky! ) for links to get the downloads