Help find a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff

Is Rogers Cable their ISP??? :crazy_face:

Show’s over, folks! Move along! Nothing to see here!

Smash it with your hulk hands!!!

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Research update from the SCC team

A short research update from the Smash Childhood Cancer team


Project: Smash Childhood Cancer

Published on: 27 Jul 2022


Dear volunteers, we have received some insightful research news from the Smash Childhood Cancer team that we would like to share with you! During the restart process, the researchers at SCC have been hard at work discovering more ways to prevent cancer among children, and we can’t wait to assist them in their research soon. Here is what they shared with us:

“β-catenin (CTNNB1) is an important part of the Wnt/β-catenin signaling pathway, which is involved in the regulation of embryonic development and maintenance of organs and tissues. Activation of Wnt/β-catenin signaling cascade inhibits degradation of β-catenin, which in turn stimulates transcription of downstream target genes.

Abnormal activation of β-catenin signaling is found in >70% of colorectal cancers and several pediatric tumors such as hepatoblastoma and craniopharyngioma. Activated β-catenin promotes cancer cell proliferation, survival and migration.
Therefore, targeting β-catenin strategies have been attempted by researchers but no definite effective options are available yet. Identifying specific inhibitors against β-catenin protein binding domains is one of our projects in Smash Childhood Cancers program. Tyuji Hoshino has synthesized >150 chemical compounds targeting β-catenin binding sites based on the information generated by the massive computer network donated by the volunteers. Ching Lau and Godfrey Chan have been verifying the in vitro and in vivo activities of some of the novel compounds generated, with the intention of possible clinical translation in the future.”

Adapted from Bubus 12, Wikipedia (June 2013)
Adapted from Bubus 12, Wikipedia (June 2013)

Thanks for reading!

The World Community Grid team

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Rain in Africa
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Just because I like you guys so much and don’t want you to injure a finger clicking on that link, I’ll post the text of it here:

Here’s the monthly update on World Community Grid points:

Statistics last updated: 2/27/22 23:59:59 (UTC) [3,690 hour(s) ago]

#N/A

Available WCG Projects

#NULL!

WCG discussion forums can be found here .

Here’s the monthly update on Folding@Home points:

                          Monthly
Name            Credit     Change
1695814     23,506,151  2,145,069
Celalta      6,419,290  1,353,412
Breadmaker   3,414,429     57,983
GoA_Kenny    3,177,692    613,789

Typical Folding@Home Projects

COVID-19
Alzheimer’s
Cancer
Huntington’s
Parkinson’s
For a comprehensive list see https://apps.foldingathome.org/psummary

If you’d like to join us in finding a cure for COVID-19, Cancer, Ebola, AIDS, and other stuff, see the OP ( <-- clicky clicky! ) for links to get the downloads

Help Stop TB update…

full article text

Interview with Help Stop TB team

Learn about the current state and future plans of Help Stop TB through this brief interview


Project: Help Stop TB

Published on: 4 Aug 2022


Dear volunteers, Help Stop Tuberculosis team has been collaborating with World Community Grid for nearly two years, and has produced life-saving research results thanks to you. We hope you find this interview-style article informative and answer all of the questions you may have about their research!


What does your project aim to do?

Our project aims to study the structural and organizational properties of Mycolic Acids: very long fatty acids integral to TB’s drug resistance. Mycolic Acids are far longer than many other lipids, allowing them to fold into complex structures that a regular fatty acid could not. Mycobacterium tuberculosis bacteria use these complex structures to create a near impenetrable cell wall by fitting Mycolic Acids together like puzzle pieces, preventing drugs and our immune cells from doing their jobs effectively.

We create simulations of Mycolic Acids folding over time to map out their folding behavior and understand how the shapes they adopt change the properties they display - however, to do this we need to generate hundreds of potential combinations of different acids, under different temperature and solvent conditions. This is where the World Community Grid is essential, as such large-scale simulations and analysis would not be possible without the help of many volunteers to provide the computing power.

Our work comes with a range of exciting potential future applications: Firstly, understanding how Mycolic Acids strengthen the cell wall will enable more informed drug design. If we know how it works, we can learn how to break it! Secondly, we can use the knowledge gained on the Mycolic Acids to design our own resilient cell walls (for example in industrially-used microbes to make them more robust), and more broadly to benefit research into other highly flexible and “bendy” molecules.

How was the project affected by the WCG downtime period?

The downtime has allowed us to consolidate the data computed by WCG thus far, and allowed us to further develop the ideas for new aspects of the research, including our own “wiggle parameter” to describe the flexibility of the molecules. We’ve also had an integral and valued team-member, Christof Jäger, leave the project for new pastures, so we have been carefully planning our next steps to accommodate this loss.

What has your research achieved so far?

Through the volunteers’ help, we have one of the largest flexible molecular dynamics data sets and have made rapid progress on understanding highly challenging dynamic systems. This opens up new uses for machine learning and provides different perspectives on the problem of clustering data - a major difficulty at present. It offers us the potential for new perspectives on other exciting chemical systems that have been to date difficult to analyze due to their dynamics, such as intrinsically disordered proteins.

What can the volunteers do?

We appreciate the support and enthusiasm of the volunteers in the forums - the moral support is invaluable when the science gets challenging. Volunteers can always help further when they raise awareness in the community of the valuable WCG projects and their wider impact. This is particularly important for our project as we are seeing a resurgence of TB worldwide on the back of the COVID pandemic. Here, education on how harmful the disease can be, why we are seeing antibiotic resistance, and the importance of global vaccination programmes is key.

Are there any expansions or new projects being considered for the near future?

On the back of the new analytical tools we have been developing with the current dataset, we are considering expanding our molecules to the pathogenetically important cord-factors - medically important derivatives of the mycolic acids we have already looked at. This will provide additional insight into how the chemical coupling of mycolic acids changes their behavior and allows us to further develop our ideas around cell-wall models for TB.


Thank you to Dr. Anna K. Croft for your contribution, as well as the rest of the HSTB team for their part in building a better world.

The World Community Grid team

While waiting for this thing to go somewhere, I decided to shift priority and help find amicable numbers.
However I started noticing that at times when I was watching youtube or even a movie in my computer’s DVD, occasionally the video would lag. My bro-in-law advised I watch on Task manager and sure enough the next time it happened a program named Amicable v3_03 popped up and hogged all my CPU resources for about 10 seconds. This was annoying so I uninstalled BOINC; perhaps I will reinstall it when things get moving, but I thought this was odd.

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