The GLP-1 Thread

Their pocketbook, I guess. Rx Co’s will have a solution for that, though.

one of the posters mentioned that they are going generic in canada soon. so that will reinvigorate the “prescription drugs from canada” excitement and make them pretty affordable. or affordable enough.

I have a liver condition for which Wegovy has been approved for treatment. I might be on it for quite some time.

Googling around, the cost to manufacture this stuff is negligible. So maybe one day, after pharma makes their $trillion, everyone will just be on GLP-1s all the time for no reason.

https://qz.com/ozempic-5-cost-study-1851370294

The grey market has already taken a big chunk. You can be on this stuff for less than $100 a month if you know the right vocabulary to search for it.

i assume it would still qualify for HSA/FSA account use through these places?

Definitely not, as it is not necessarily legal.

Jiayou!

People are eating less so they are looking to buy more nutrient dense foods.

The market in the UK is responding to this change by offering more higher protein, nutrient rich foods.

I see this as a good thing.

I’m on Zepbound paying cash $499 for 4 vials, and I take a shot every 10 days instead of every 7. 12 bucks a day is cheaper than the extra food I was eating…

I’m down 35 pounds and still losing. But a monthago I got bloodwork and ALL my numbers were I’mthe good range, numbers that weren’t good when I was 40 lbs lighter and 20 years younger. I’m going off my BP med, which I went on at a lower weight than I am now. And I’m doing this all while staying on the second lowest dose.

For those of you still morally opposed to this…I can’t convey to you what a game changer this is. But also, if how I feel about food while on this drug is how you normally feel, I sort of understand the lack of sympathy. If this was how I felt all the time I’d probably think the same way.

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I forgot about this. In the US you do not have multi-dose pens like in the UK. The multi-dose pens in the UK (4 doses for 1 month) have a huge amount of over-fill so you can extract a 5th dose from them quite easily. A lot of people do this now to keep the costs down long-term (15mg pens are going for £300 now ($420)).

On this drug, I literally forget to eat sometimes. I have several times put lunch in the microwave, gone back to work, and two hours later realized I forgot to take it out. The orher strange effect I’ve noticed is when I sit down to eat, my mouth starts watering even though I’m not feeling a need to eat.

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Yeah, I was well aware that I needed to be on this GLP-1 drug forever for it to work… did people not know that already? Or is my doctor just really good at her job?

I’m rooting for you, Loner!
I’m morally opposed to people lying about not taking it when they are. But, that is just being my being morally opposed to lying in general.

There might still be hope that better eating habits could be learned while on the drug?

I don’t have any sort of moral objection to people on the drugs, I just think the state of food, diet, and understanding of all of that in the US is just horrible. Nearly every person who diets rewards themself with food at the end of the diet, or part of the diet is including reward days. Temporary modifications just result it ending up at the same weight within a year or two. There are a number of similarities between alcohol and sugar when it comes to dopamine, cravings, addiction, damage and inflammation that they cause to the body, etc. It’s widely recognized that with alcohol, abstinence is the sustainable solution, but with sugar, its cut back, lose weight, the go back to “normal”.

For me personally, i have long avoided keeping sugary things at home. If I take a piece of candy from the bowl near my office, I will almost certainly be back several times a day until I decide to suffer through a few days of cravings to break the cycle. I decided, this isn’t worth it. One piece was never one piece. Alcohol, pretty much the same thing - as long as it was around, it was something I craved. Once it was gone, it was pretty easy forget about it completely.

I won’t say that everyone works the same way that I do, but I also know that I am not special, or unique in this sense. These addictions have so much in common yet we approach them completely differently because one substance causes intoxication and the other does not. That’s an important distinction of course, and the impact it can have on those around them that makes alcohol a bigger “problem” but then that sort of obscures what might be a perfectly viable drug free option for many, and that is simply a commitment to abstain from sugar.

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I’m not saying that I wasn’t, and probably still am, addicted to sugar. But again, diet never really caused my weight problems in the first place. My nutritionist was supremely unhelpful in that all she could tell me was that I’m not eating enough. And despite the sugar thing, I never qualified as having a binge eating problem. I gained a lot of the weight from antidepressant usage (and 40+ pounds down that weight is now gone).

And to be clear - while I was still 115 pounds soaking wet, my cholesterol was persistently high. This drug is changing all that. I don’t even really care what my weight is anymore - the benefits I’m getting in terms of the health markers (like lower cholesterol) are too good to ignore.

So yes, anecdotal evidence sample size of 1, but not all weight problems are because of food.

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The US has finally decided to join the ROW with multi-dose pens.

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I started on Zepbound just over a month ago (multi-dose pen the whole time). First 2 weeks at 2.5mg was rough, and this first week at 5mg has been rougher side effect wise, but overall it’s really helped. I used to stress eat a lot, and now I find healthier ways to deal with it all because I just don’t need to eat that much. I have a 3 month follow up to check in, but unless the side effects keep getting worse, I don’t think I’ll be looking to stop it.

My biggest concern is it is counter-indicated for oral estrodiol birth control (it basically makes the BC ineffective), so I’m waiting on blood work to see if it’s also reducing the effectiveness of my HRT. I get the sense that it is because of some other symptoms I’ve been having, though it can be hard to separate low E side effects from the Zepbound side effects.

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Going to be interesting to start seeing these %'s drop based on what is happening globally at the developed country level.